Grapefruit FAQ Grapefruit and grapefruit juice can be a part of a healthy diet for most people. Share on Facebook Share on Twitter Potential Drug Interactions with Grapefruit Many prescription and non-prescription medications may interact with grapefruit and grapefruit juices. If you enjoy grapefruit products, talk to your physician to see if any of your medications may interact with grapefruit. Your physician may be able to recommend a non-interacting alternative drug that will effectively treat your health condition while allowing you to enjoy grapefruit and grapefruit juice. FAQ: Grapefruit juice–drug interactions Q: What causes grapefruit and grapefruit juice to interact with certain medications? A: Grapefruits contain natural substances called furanocoumarins, which can interfere with intestinal enzymes that break down certain medications in your digestive system. This interaction can result in a medication staying in your body for too short of a time—causing a decrease in its effectiveness—or a medication staying in your body for too long—increasing its effect to potentially dangerous levels. Q: Which drugs interact with grapefruit juice? A: According to the FDA, grapefruit juice can interact with the following types of medicationi: Some statin drugs to lower cholesterol, such as Zocor (simvastatin), Lipitor (atorvastatin) and Pravachol (pravastatin) Some blood pressure-lowering drugs, such as Nifediac and Afeditab (both nifedipine) Some organ transplant rejection drugs, such as Sandimmune and Neoral (both cyclosporine) Some anti-anxiety drugs, such as BuSpar (buspirone) Some anti-arrhythmia drugs, such as Cordarone and Nexterone (both amiodarone) Some antihistamines, such as Allegra (fexofenadine) Enjoying Grapefruit Safely If you have questions about whether you can have fresh grapefruit or grapefruit juice while using your medication, talk to your doctor, your pharmacist or another health care professional. If you have a prescription that is known to interact with grapefruit, your doctor may be able to prescribe an alternative. Consult the Medication Guide or patient information sheet that comes with your prescription medicine. Some may advise not to take the drug with grapefruit juice. If it’s OK to have grapefruit juice, there will be no mention of it in the guide or information sheet. Read the Drug Facts label on your non-prescription medicine, which will let you know if you shouldn’t have grapefruit or other fruit juices with it. For more information, consult the Food and Drug Administration website (www.fda.gov) The information on this website is for the sole purpose of educating visitors on the grapefruit and cranberry. The findings, views, and opinions of scientists, health professionals and others expressed on this website are theirs alone. Ocean Spray is providing access to this information so that the public can form their own opinions. iU.S. Food and Drug Administration. Grapefruit Juice and Medicine May Not Mix. http://www.fda.gov/forconsumers/consumerupdates/ucm292276.htm. Accessed June 30, 2014.